abstract：:Automated image analysis of cells and tissues has been an active research field in medical informatics for decades but has recently attracted increased attention due to developments in computer and microscopy hardware and the awareness that scientific and diagnostic pathology require novel approaches to perform object...

journal_title：Scientific reports

authors： Wienert S,Heim D,Saeger K,Stenzinger A,Beil M,Hufnagl P,Dietel M,Denkert C,Klauschen F

更新日期：2012-01-01 00:00:00

abstract：:Porphyry systems supply most copper and significant gold to our economy. Recent studies indicate that they are frequently associated with high Sr/Y magmatic rocks, but the meaning of this association remains elusive. Understanding the association between high Sr/Y magmatic rocks and porphyry-type deposits is essential...

journal_title：Scientific reports

authors： Chiaradia M,Ulianov A,Kouzmanov K,Beate B

更新日期：2012-01-01 00:00:00

abstract：:Infectious diseases outbreaks are often characterized by a spatial component induced by hosts' distribution, mobility, and interactions. Spatial models that incorporate hosts' movements are being used to describe these processes, to investigate the conditions for propagation, and to predict the spatial spread. Several...

journal_title：Scientific reports

authors： Poletto C,Tizzoni M,Colizza V

更新日期：2012-01-01 00:00:00

abstract：:In humans, oxytocin (OT) enhances prosocial behaviour. However, it is still unclear how the prosocial effects of OT are modulated by emotional features and/or individuals' characteristics. In a placebo-controlled design, we tested 20 healthy male volunteers to investigate these behavioural and neurophysiological modul...

journal_title：Scientific reports

authors： Hirosawa T,Kikuchi M,Higashida H,Okumura E,Ueno S,Shitamichi K,Yoshimura Y,Munesue T,Tsubokawa T,Haruta Y,Nakatani H,Hashimoto T,Minabe Y

更新日期：2012-01-01 00:00:00

abstract：:The roles of multifunctional CD4 T cells in human tuberculosis are not well defined. In this study, we found that patients with tuberculosis had decreased PMA/ionomycin stimulated multifunctional CD4 T cells, and increased Mycobacterium tuberculosis antigen-specific multifunctional CD4 T cells, when compared to indivi...

journal_title：Scientific reports

authors： Qiu Z,Zhang M,Zhu Y,Zheng F,Lu P,Liu H,Graner MW,Zhou B,Chen X

更新日期：2012-01-01 00:00:00

abstract：:Graphene and related materials have come to the forefront of research in electrochemical sensors during recent years due to the promising properties of these nanomaterials. Further applications of these nanomaterials have been hampered by insufficient sensitivity offered by these nanohybrids for the type of molecules ...

journal_title：Scientific reports

authors： Sharma P,Bhalla V,Dravid V,Shekhawat G,Jinsong-Wu,Prasad ES,Suri CR

更新日期：2012-01-01 00:00:00

abstract：:A loss of function mutation in the TRESK K2P potassium channel (KCNK18), has recently been linked with typical familial migraine with aura. We now report the functional characterisation of additional TRESK channel missense variants identified in unrelated patients. Several variants either had no apparent functional ef...

journal_title：Scientific reports

authors： Andres-Enguix I,Shang L,Stansfeld PJ,Morahan JM,Sansom MS,Lafrenière RG,Roy B,Griffiths LR,Rouleau GA,Ebers GC,Cader ZM,Tucker SJ

更新日期：2012-01-01 00:00:00

abstract：:The relationship between the cuprate pseudogap (Δ(p)) and superconducting gap (Δ(s)) remains an unsolved mystery. Here, we present a temperature- and doping-dependent tunneling study of submicron Bi(2)Sr(2)CaCu(2)O(8+δ) intrinsic Josephson junctions, which provides a clear evidence that Δ(s) closes at a temperature T(...

journal_title：Scientific reports

authors： Ren JK,Zhu XB,Yu HF,Tian Y,Yang HF,Gu CZ,Wang NL,Ren YF,Zhao SP

更新日期：2012-01-01 00:00:00

abstract：:Flavivirus-mediated inflammation causes neuronal death, but whether the infected neurons can evoke an innate immune response to elicit their own protection, is unknown. In an earlier study we have shown that neuronal RIG-I, play a significant role in inducing production and release of molecules that are related to inf...

journal_title：Scientific reports

authors： Nazmi A,Mukhopadhyay R,Dutta K,Basu A

更新日期：2012-01-01 00:00:00

abstract：:To better understand the recognition mechanism of RISC and the repertoire of guide-target interactions we introduced G:U wobbles and mismatches at various positions of the microRNA (miRNA) 'seed' region and performed all-atom molecular dynamics simulations of the resulting Ago-miRNA:mRNA ternary complexes. Our simulat...

journal_title：Scientific reports

authors： Xia Z,Clark P,Huynh T,Loher P,Zhao Y,Chen HW,Ren P,Rigoutsos I,Zhou R

更新日期：2012-01-01 00:00:00

abstract：:Spintronic devices currently rely on magnetic switching or controlled motion of domain walls by an external magnetic field or spin-polarized current. Achieving the same degree of magnetic controllability using an electric field has potential advantages including enhanced functionality and low power consumption. Here w...

journal_title：Scientific reports

authors： Lahtinen TH,Franke KJ,van Dijken S

更新日期：2012-01-01 00:00:00

abstract：:We report the impact of anti-urothelial autoantibody (AUAb) on urinary bladder phenotype in BALB/c mice deficient of the FcγRIIb and PD-1. AUAb was present in serum samples from approximately half of the double-knockout (DKO) mice, as detected by immunofluorescence and immunoblots for urothelial proteins including uro...

journal_title：Scientific reports

authors： Sugino Y,Nishikawa N,Yoshimura K,Kuno S,Hayashi Y,Yoshimura N,Okazaki T,Kanematsu A,Ogawa O

更新日期：2012-01-01 00:00:00

abstract：:The Early Cretaceous Greater Ontong Java Event in the Pacific Ocean may have covered ca. 1% of the Earth's surface with volcanism. It has puzzled scientists trying to explain its origin by several mechanisms possible on Earth, leading others to propose an extraterrestrial trigger to explain this event. A large oceanic...

journal_title：Scientific reports

authors： Tejada ML,Ravizza G,Suzuki K,Paquay FS

更新日期：2012-01-01 00:00:00

abstract：:Various methods for the direct reprogramming of human somatic cells have been developed. However, a therapeutic method to reprogram and eliminate human solid tumor cells has not been developed. Here we show a novel therapeutic method to reprogram and eliminate human solid tumor cells with chemicals. This therapeutic m...

journal_title：Scientific reports

authors： Moriguchi H,Zhang Y,Mihara M,Sato C

更新日期：2012-01-01 00:00:00

abstract：:We propose a model of a learning agent whose interaction with the environment is governed by a simulation-based projection, which allows the agent to project itself into future situations before it takes real action. Projective simulation is based on a random walk through a network of clips, which are elementary patch...

journal_title：Scientific reports

authors： Briegel HJ,De las Cuevas G

更新日期：2012-01-01 00:00:00

abstract：:Science, being a social enterprise, is subject to fragmentation into groups that focus on specialized areas or topics. Often new advances occur through cross-fertilization of ideas between sub-fields that otherwise have little overlap as they study dissimilar phenomena using different techniques. Thus to explore the n...

journal_title：Scientific reports

authors： Pan RK,Sinha S,Kaski K,Saramäki J

更新日期：2012-01-01 00:00:00

abstract：:Cold atmospheric plasma (CAP), a technology based on quasi-neutral ionized gas at low temperatures, is currently being evaluated as a new highly selective alternative addition to existing cancer therapies. Here, we present a first attempt to identify the mechanism of CAP action. CAP induced a robust ~2-fold G2/M incre...

journal_title：Scientific reports

authors： Volotskova O,Hawley TS,Stepp MA,Keidar M

更新日期：2012-01-01 00:00:00

abstract：:Nonperturbing and simple transfection methods are important for modern techniques used in biotechnology. Recently, we reported that electrospraying can be applied to DNA transfection in cell lines, bacteria, and chicken embryos. However, the transfection efficiency was only about 2%. To improve the transfection rate, ...

journal_title：Scientific reports

authors： Ikemoto K,Sakata I,Sakai T

更新日期：2012-01-01 00:00:00

abstract：:Friction is a major inhibitor in almost every mechanical system. Enlightened by the Leidenfrost effect - a droplet can be levitated by its own vapor layer on a sufficiently hot surface - we demonstrate for the first time that a small cart can also be levitated by Leidenfrost vapor. The levitated cart can carry certain...

journal_title：Scientific reports

authors： Hashmi A,Xu Y,Coder B,Osborne PA,Spafford J,Michael GE,Yu G,Xu J

更新日期：2012-01-01 00:00:00

abstract：:In recent years, the topic of noise in the sea and its effects on marine mammals has attracted considerable attention from both the scientific community and the general public. Since marine mammals rely heavily on acoustics as a primary means of communicating, navigating, and foraging in the ocean, any change in their...

journal_title：Scientific reports

authors： Frisk GV

更新日期：2012-01-01 00:00:00

abstract：:We report the development of complete structural AlGaN-based deep-ultraviolet light-emitting diodes with an aluminum thin layer for increasing light extraction efficiency. A 217% enhancement in peak photoluminescence intensity at 294 nm is observed. Cathodoluminescence measurement demonstrates that the internal quantu...

journal_title：Scientific reports

authors： Gao N,Huang K,Li J,Li S,Yang X,Kang J

更新日期：2012-01-01 00:00:00

abstract：:How microgravitational space environments affect aging is not well understood. We observed that, in Caenorhabditis elegans, spaceflight suppressed the formation of transgenically expressed polyglutamine aggregates, which normally accumulate with increasing age. Moreover, the inactivation of each of seven genes that we...

journal_title：Scientific reports

authors： Honda Y,Higashibata A,Matsunaga Y,Yonezawa Y,Kawano T,Higashitani A,Kuriyama K,Shimazu T,Tanaka M,Szewczyk NJ,Ishioka N,Honda S

更新日期：2012-01-01 00:00:00

abstract：:MicroRNAs can promote translation of specific mRNAs in quiescent (G0) mammalian cells and immature Xenopus laevis oocytes. We report that microRNA-mediated upregulation of target mRNAs in oocytes is dependent on nuclear entry of the microRNA; cytoplasmically-injected microRNA repress target mRNAs. Components of the ac...

journal_title：Scientific reports

authors： Truesdell SS,Mortensen RD,Seo M,Schroeder JC,Lee JH,LeTonqueze O,Vasudevan S

更新日期：2012-01-01 00:00:00

abstract：:Quantum coherence is one of the primary non-classical features of quantum systems. While protocols such as the Leggett-Garg inequality (LGI) and quantum tomography can be used to test for the existence of quantum coherence and dynamics in a given system, unambiguously detecting inherent "quantumness" still faces serio...

journal_title：Scientific reports

authors： Li CM,Lambert N,Chen YN,Chen GY,Nori F

更新日期：2012-01-01 00:00:00

abstract：:As antibody-based diagnosis and therapy grow at an increased pace, there is a need for methods which rapidly and accurately determine antibody-antigen interactions. Here, we report a method for the multiplex determination of antibody epitopes using bacterial cell-surface display. A protein-fragment library with 10(7) ...

journal_title：Scientific reports

authors： Hudson EP,Uhlen M,Rockberg J

更新日期：2012-01-01 00:00:00

abstract：:Organ regenerative therapy aims to reproduce fully functional organs to replace organs that have been lost or damaged as a result of disease, injury, or aging. For the fully functional regeneration of ectodermal organs, a concept has been proposed in which a bioengineered organ is developed by reproducing the embryoni...

journal_title：Scientific reports

authors： Asakawa K,Toyoshima KE,Ishibashi N,Tobe H,Iwadate A,Kanayama T,Hasegawa T,Nakao K,Toki H,Noguchi S,Ogawa M,Sato A,Tsuji T

更新日期：2012-01-01 00:00:00

abstract：:Major overturn within a magma chamber can bring together felsic and mafic magmas, prompting de-volatilisation and acting as the driver for Plinian eruptions. Until now identification of mixing has been limited to analysis of lavas or individual crystals ejected during eruptions. We have recovered partially developed c...

journal_title：Scientific reports

authors： Stock MJ,Taylor RN,Gernon TM

更新日期：2012-01-01 00:00:00

abstract：:Fibrin polymerization is a necessary part of hemostasis but clots can obstruct blood vessels and cause heart attacks and strokes. The polymerization reactions are specific and controlled, involving strong knob-into-hole interactions to convert soluble fibrinogen into insoluble fibrin. It has long been assumed that clo...

journal_title：Scientific reports

authors： Chernysh IN,Nagaswami C,Purohit PK,Weisel JW

更新日期：2012-01-01 00:00:00

abstract：:Cellular reprogramming involves profound alterations in genome-wide gene expression that is precisely controlled by a hypothetical epigenetic code. Small molecules have been shown to artificially induce epigenetic modifications in a sequence independent manner. Recently, we showed that specific DNA binding hairpin pyr...

journal_title：Scientific reports

authors： Pandian GN,Nakano Y,Sato S,Morinaga H,Bando T,Nagase H,Sugiyama H

更新日期：2012-01-01 00:00:00

abstract：:If the components of a battery, including electrodes, separator, electrolyte and the current collectors can be designed as paints and applied sequentially to build a complete battery, on any arbitrary surface, it would have significant impact on the design, implementation and integration of energy storage devices. Her...

journal_title：Scientific reports

authors： Singh N,Galande C,Miranda A,Mathkar A,Gao W,Reddy AL,Vlad A,Ajayan PM

更新日期：2012-01-01 00:00:00

abstract：:We study an Ising chain undergoing a quantum phase transition in a quantum magnetic field. Such a field can be emulated by coupling the chain to a central spin initially in a superposition state. We show that--by adiabatically driving such a system--one can prepare a quantum superposition of any two ground states of t...

journal_title：Scientific reports

authors： Rams MM,Zwolak M,Damski B

更新日期：2012-01-01 00:00:00

abstract：:Here we construct mechanically flexible and optically transparent thin film solid state supercapacitors by assembling nano-engineered carbon electrodes, prepared in porous templates, with morphology of interconnected arrays of complex shapes and porosity. The highly textured graphitic films act as electrode and curren...

journal_title：Scientific reports

authors： Jung HY,Karimi MB,Hahm MG,Ajayan PM,Jung YJ

更新日期：2012-01-01 00:00:00

abstract：:A histoanatomical context is imperative in an analysis of gene expression in a cell in a tissue to elucidate physiological function of the cell. In this study, we made technical advances in fluorescence laser microdissection (LMD) in combination with the absolute quantification of small amounts of mRNAs from a region ...

journal_title：Scientific reports

authors： Yoshioka W,Endo N,Kurashige A,Haijima A,Endo T,Shibata T,Nishiyama R,Kakeyama M,Tohyama C

更新日期：2012-01-01 00:00:00

abstract：:β1 integrin regulates the response of both normal and cancer cells to their local environment. Although mis-localised in prostate cancer, the role β1 integrin plays in prostate development and carcinogenesis remains unknown. To assess the role of β1 integrin in vivo, we conditionally deleted β1 integrin from prostate ...

journal_title：Scientific reports

authors： Moran-Jones K,Ledger A,Naylor MJ

更新日期：2012-01-01 00:00:00

abstract：:The actinopterygians comprise nearly one-half of all extant vertebrate species and are very important for human well-being. However, the phylogenetic relationships among certain groups within the actinopterygians are still uncertain, and debates about these relationships have continued for a long time. Along with the ...

journal_title：Scientific reports

authors： Zou M,Guo B,Tao W,Arratia G,He S

更新日期：2012-01-01 00:00:00

abstract：:Aerogels have numerous applications due to their high surface area and low densities. However, creating aerogels from a large variety of materials has remained an outstanding challenge. Here, we report a new methodology to enable aerogel production with a wide range of materials. The method is based on the assembly of...

journal_title：Scientific reports

authors： Jung SM,Jung HY,Dresselhaus MS,Jung YJ,Kong J

更新日期：2012-01-01 00:00:00

abstract：:The molecular mechanisms underlying viral pathogenesis are yet poorly understood owed to the large number of factors involved and the complexity of their interactions. Could we identify a minimal set of host transcription factors (TF) whose misregulation would result in the transcriptional profile characteristic of in...

journal_title：Scientific reports

authors： Carrera J,Elena SF

更新日期：2012-01-01 00:00:00

abstract：:Nanoscale real-time molecular sensing requires large signal enhancement, small background, short detection time and high spectral resolution. We demonstrate a new vibrational spectroscopic technique which satisfies all of these conditions. This time-resolved surface-enhanced coherent anti-Stokes Raman scattering (tr-S...

journal_title：Scientific reports

authors： Voronine DV,Sinyukov AM,Hua X,Wang K,Jha PK,Munusamy E,Wheeler SE,Welch G,Sokolov AV,Scully MO

更新日期：2012-01-01 00:00:00

abstract：:The bulk-insulating topological insulators with tunable surface states are necessary for applications in spintronics and quantum computation. Here we present theoretical evidence for modulating the topological surface states and achieving the insulating bulk states in solid-solution (Bi(1-x)Sb(x))(2)Te(3). Our results...

journal_title：Scientific reports

authors： Niu C,Dai Y,Zhu Y,Ma Y,Yu L,Han S,Huang B

更新日期：2012-01-01 00:00:00

abstract：:Based on the polarization-sensitive absorption of graphene under conditions of total internal reflection, a novel optical sensor combining graphene and a microfluidic structure was constructed to achieve the sensitive real-time monitoring of refractive indexes. The atomic thickness and strong broadband absorption of g...

journal_title：Scientific reports

authors： Xing F,Liu ZB,Deng ZC,Kong XT,Yan XQ,Chen XD,Ye Q,Zhang CP,Chen YS,Tian JG

更新日期：2012-01-01 00:00:00